Ammonia → HCID 19920015, compound

HRID 1648423Notes

Reaction equation

HRID 1648423 reaction equation
Br[CH:2]([C:4]#[C:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[CH3:3].[NH3:13]>CCOCC>[ClH:12].[NH2:13][CH:2]([C:4]#[C:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[CH3:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19920017HCID 19920017, compound

Product 1

HCID 19920015HCID 19920015, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The product prepared in step (e) above is added, with stirring, to 5 to 10 times excess of ammonia. The mixture is stirred at room temperature for 3 hours. An excess of ether is then added and the precipitate is filtered off. The ether is removed in vacuo and the resulting oil is used directly to prepare the hydrochloride salt.

Workup

  1. filtrationthe precipitate is filtered off
  2. customThe ether is removed in vacuo
  3. customto prepare the hydrochloride salt

Sources & evidence

ORD record
ord-959750ab866e418085985bdf8984c4d6
Source dataset
uspto-grants-1995_07
Patent number
US05436273

Reaction notes

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