HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 86748809, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Copper sulfate pentahydrate | HCID 24463 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE | HCID 603633 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | HCID 86748809 | HCID 86748809 | 91% |
Reaction Steps
To a solution of copper sulfate pentahydrate (0.098 mol), under nitrogen, in 100 ml of 28% ammonium hydroxide and water (315 ml), hydroxylamine hydrochloride (0.175 mol) is added. After the change in color (blue to green) 62.5 ml of acetone is added. Immediately afterwards, a solution of 2-phthalimido-3-butyne (0.0875 mol) in 280 ml of acetone is added. After 5 minutes of vigorous stirring, a solution of 30.8 ml of glacial acetic acid in 455 ml of water is added. The yellow precipitate is filtered off, washed and dried in vacuo to yield the title product (yield 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436273 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-2c51e450be4e45af9b524bcf7517e26c |
| Source note | uspto-grants-1995_07 |