p-Toluenesulfonic acid 1-butyn-3-yl ester → 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE

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Reaction Steps

To a solution of potassium phthalimide (0.275 mole; 5.1 g) in DMF (20 ml), 2-tosyloxy-3-butyne (0.25 mole) is added and allowed to react for 3 hours at 70° C. After cooling, the reaction mixture is extracted with chloroform and the chloroform layer is washed and dried. Removal of the chloroform, in vacuo, yields crude 2-phthalimido-3-butyne.

Provenance & Evidence