反应详情

To a solution of potassium phthalimide (0.275 mole; 5.1 g) in DMF (20 ml), 2-tosyloxy-3-butyne (0.25 mole) is added and allowed to react for 3 hours at 70° C. After cooling, the reaction mixture is extracted with chloroform and the chloroform layer is washed and dried. Removal of the chloroform, in vacuo, yields crude 2-phthalimido-3-butyne.

1. customto react for 3 hours at 70° C
2. temperatureAfter cooling
3. extractionthe reaction mixture is extracted with chloroform
4. washthe chloroform layer is washed
5. customdried
6. customRemoval of the chloroform