Trifluoroacetic acid → HCID 86748815, compound

HRID 1648460Notes

Reaction equation

HRID 1648460 reaction equation
C(OC([NH:8][C@H:9]([CH2:45][CH:46]([CH3:48])[CH3:47])[CH2:10][O:11][C:12]1[CH:44]=[CH:43][C:15]([CH2:16][CH:17]2[S:21][C:20](=[O:22])[N:19](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:18]2=[O:42])=[CH:14][CH:13]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:8][C@H:9]([CH2:45][CH:46]([CH3:48])[CH3:47])[CH2:10][O:11][C:12]1[CH:44]=[CH:43][C:15]([CH2:16][CH:17]2[S:21][C:20](=[O:22])[NH:19][C:18]2=[O:42])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22854986HCID 22854986, compound

Product 1

HCID 86748815HCID 86748815, compoundYield 128.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A procedure similar to that described in Preparation 2, above, was followed, but using 1.03 g of 5-{4-[2(R)-t-butoxycarbonylamino-4-methylpentyloxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione [prepared as described in Preparation 16], 10 ml of methylene chloride and 10 ml of trifluoroacetic acid. After completion of the reaction, the methylene chloride and trifluoroacetic acid were removed by distillation under reduced pressure, and the residue was washed with toluene to give 640 mg of the title compound.

Workup

  1. customA procedure similar to that described in Preparation 2
  2. customAfter completion of the reaction
  3. customthe methylene chloride and trifluoroacetic acid were removed by distillation under reduced pressure
  4. washthe residue was washed with toluene

Sources & evidence

ORD record
ord-9fac7832b7fa475ab21266e711d36a45
Source dataset
uspto-grants-1995_07
Patent number
US05436257

Reaction notes

Loading…