反应详情

温度

40 °C

121 g (1 mol) of benzamide in 3 l of toluene are introduced initially, 200 g of powdered potassium hydroxide are introduced with stirring, 32 g (0.1 mol) of tetrabutylammonium bromide are added and the mixture is heated to 40° C. 243 g (1 mol) of 88% cis-1,4-dibromo-2-butene are then added dropwise in such a way that the internal temperature does not exceed 60° C. The mixture is stirred for another 5 hours at 50° C., then poured into water, and the organic phase is separated off, washed with water, dried and concentrated. The residue is distilled under reduced pressure.

1. customdoes not exceed 60° C
2. stirringThe mixture is stirred for another 5 hours at 50° C.
3. customthe organic phase is separated off
4. washwashed with water
5. customdried
6. concentrationconcentrated
7. distillationThe residue is distilled under reduced pressure