Water → 154678-67-8

HRID 1648484Notes

Reaction equation

HRID 1648484 reaction equation
[CH3:1][O:2][CH:3]([O:12][CH3:13])[CH2:4][C:5]1([C:10]#[N:11])[CH2:9][CH2:8][CH2:7][CH2:6]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)(=O)C.O>CCOCC>[CH3:13][O:12][CH:3]([O:2][CH3:1])[CH2:4][C:5]1([CH2:10][NH2:11])[CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 19920130HCID 19920130, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 54429804154678-67-8Yield 88%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

54 mmol of the product obtained in Stage A, in 100 ml of ether, are added dropwise to 109 mmol of lithium aluminum hydride suspended in 200 ml of ether stirred at room temperature under a nitrogen atmosphere. When all the nitrile has disappeared, 10 ml of ethyl acetate are added to the mixture, followed by 10 ml of water. The mixture is stirred for 1 hour, filtered and dried over MgSO4 and the solvent is evaporated off. The expected product is obtained in an 88% yield.

Workup

  1. stirringThe mixture is stirred for 1 hour
  2. filtrationfiltered
  3. dry with materialdried over MgSO4
  4. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-a683711788b8411f8ee16a196d792f1c
Source dataset
uspto-grants-1995_07
Patent number
US05436343

Reaction notes

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