Water → HCID 19920124, compound

HRID 1648486Notes

Reaction equation

HRID 1648486 reaction equation
[CH3:1][O:2][CH:3]([O:15][CH3:16])[CH2:4][CH2:5][C:6]1([C:11](OC)=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>CCOCC>[CH3:16][O:15][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][C:6]1([CH2:11][OH:12])[CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 962WaterHCID 19920119HCID 19920119, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19920124HCID 19920124, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 0.25 mol of the compound prepared in Stage A of Example 10 in 200 ml of ether is added dropwise to a suspension, stirred at 0° C., of 0.25 mol of lithium aluminum hydride in 200 ml of ether. When the addition is complete, the reaction medium is allowed to return to room temperature, and is then stirred for 4 hours at this temperature before being hydrolyzed by adding 20 ml of water. The salts are filtered off and washed twice with ether, and the filtrate is dried and concentrated.

Workup

  1. additionWhen the addition
  2. customto return to room temperature
  3. filtrationThe salts are filtered off
  4. washwashed twice with ether
  5. customthe filtrate is dried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-ea07737e8750454e85fa7e34e2ce279a
Source dataset
uspto-grants-1995_07
Patent number
US05436343

Reaction notes

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