反应详情

温度

0 °C

Pilocarpine hydrochloride (3.92 g; 16.00 moles) was dissolved in distilled water (4 ml) and the solution was cooled to about 0° C. To the solution 18 ml of ice cold 2M NaOH were added in four portions. The solution was left standing at about 0° C. for one hour. After neutralizing excess NaOH with 5 ml of 1M HCl, the solution was evaporated under reduced pressure. The residue was dissolved in 60 ml of absolute ethanol and mixed for 10 minutes at 60° C. After cooling to 4° C. undissolved NaCl was removed by filtration. The filtrate was evaporated under reduced pressure, whereby 3.93 g of sodium pilocarpate were obtained as a white, extremely hygroscopic substance.

1. waitThe solution was left
2. customthe solution was evaporated under reduced pressure
3. dissolutionThe residue was dissolved in 60 ml of absolute ethanol
4. additionmixed for 10 minutes at 60° C
5. temperatureAfter cooling to 4° C. undissolved NaCl
6. customwas removed by filtration
7. customThe filtrate was evaporated under reduced pressure