HCID 10098693, compound → HCID 10254585, compound

HRID 1648519Notes

Reaction equation

HRID 1648519 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:26][C:27]2[CH:39]=[CH:38][C:30]([C:31]([O:33]C(C)(C)C)=[O:32])=[CH:29][CH:28]=2)[C:7](/[CH:10]=[C:11]2\[N:12]([CH2:22][CH2:23][CH2:24][CH3:25])[C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]\2=[O:16])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>C(Cl)Cl.FC(F)(F)C(O)=O>[CH2:1]([C:5]1[N:6]([CH2:26][C:27]2[CH:39]=[CH:38][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)[C:7](/[CH:10]=[C:11]2\[N:12]([CH2:22][CH2:23][CH2:24][CH3:25])[C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]\2=[O:16])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 10098693HCID 10098693, compound

Product 1

HCID 10254585HCID 10254585, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1,1-dimethylethyl Z-4-[[2-butyl-5-[(1,3-dibutyl-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-imidazol-1-yl]methyl]benzoate (0.88 g, 1.64 mmol) was dissolved in methylene chloride (16 mL) and trifluoroacetic acid (16 mL). After stirring for 3 hours the reaction mixture was evaporated in vacuo. Dilute NaHCO3 was added to adjust the pH to 6 and extracted with ethyl acetate. This extract was dried over MgSO4 and then evaporated in vacuo and purified via chromatography (eluant methanol in chloroform).

Workup

  1. customwas evaporated in vacuo
  2. additionDilute NaHCO3 was added
  3. extractionextracted with ethyl acetate
  4. dry with materialThis extract was dried over MgSO4
  5. customevaporated in vacuo
  6. custompurified via chromatography (eluant methanol in chloroform)

Sources & evidence

ORD record
ord-61b57045b8e8452c988942677ca8ef1c
Source dataset
uspto-grants-1995_07
Patent number
US05436260

Reaction notes

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