反应详情

348 g (2 mol) of di-n-butyl carbonate and 140 g (2 mol) of potassium methoxide powder were placed together with 500 ml of 4-tert-butyltoluene in a reaction vessel equipped with a stirrer. 154 g (1 mol) of 4-tert-butylcyclohexanone were metered in at 40° C. over the course of 4 h. The mixture was subsequently stirred with 400 g of n-butanol at 110° C. for 3 h. 600 ml of 10% strength HCl were then added, forming two phases which were easily separated. The aqueous phase was extracted several times with 4-tert-butyl toluene. The combined organic phases were distilled to give 180 g of dibutyl 4-tert-butylpimelate, corresponding to a yield of 74%,

1. customequipped with a stirrer
2. customwere metered in at 40° C. over the course of 4 h
3. customforming two phases which
4. customwere easily separated
5. extractionThe aqueous phase was extracted several times with 4-tert-butyl toluene
6. distillationThe combined organic phases were distilled