Hydrochloric Acid → HCID 19030802, compound

HRID 1648577Notes

Reaction equation

HRID 1648577 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1)#[N:2].[CH2:28]([OH:30])[CH3:29].Cl>C(Cl)(Cl)Cl>[CH2:28]([O:30][C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[CH2:10][CH2:11][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:13][CH2:14]2)=[O:8])=[CH:26][CH:27]=1)=[NH:2])[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14969532HCID 14969532, compound

Product 1

HCID 19030802HCID 19030802, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-[1-(4-Cyanobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (1 g) is dissolved in chloroform (10 ml) and thereto is added ethanol (0.18 ml). Under ice cooling, hydrochloric acid gas is passed through the mixture to saturate and further the mixture is stirred at 5°-7° C. for 4 days. After the reaction, the solvent is concentrated to give 1-{1-[4-(1-ethoxy-1-iminomethyl)benzoyl]-4-piperidinyl}-3,4-dihydrocarbostyril (1 g). This product is used for the subsequent reaction.

Workup

  1. concentrationto saturate
  2. customAfter the reaction
  3. concentrationthe solvent is concentrated

Sources & evidence

ORD record
ord-f42a0139f806402d94a346abf3232ba5
Source dataset
uspto-grants-1995_07
Patent number
US05436254

Reaction notes

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