反应详情

To a solution of p-anisidine (0.11 g) in chloroform (5 ml) is added triethylamine (0.15 g) and thereto is added with stirring a solution of 4-(3,4-dihydrocarbostyril-1-yl)benzoic acid chloride obtained above in chloroform (2 ml) under ice cooling. The mixture is stirred at room temperature overnight. Water is added to the reaction mixture and the mixture is extracted with dichloromethane, washed with water and dried with magnesium sulfate. The solvent is distilled off under reduced pressure and the resulting residue is crystallized from diethyl ether and further recrystallized from ethanol/diethyl ether/n-hexane to give 1-[4-(4-methoxyanilinocarbonyl)phenyl]-3,4-dihydrocarbostyril (240 mg) as white powder, m.p.: 254°-255° C.

1. additionis added
2. extractionthe mixture is extracted with dichloromethane
3. washwashed with water
4. dry with materialdried with magnesium sulfate
5. distillationThe solvent is distilled off under reduced pressure
6. customthe resulting residue is crystallized from diethyl ether
7. customfurther recrystallized from ethanol/diethyl ether/n-hexane