Hydrochloric Acid → 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid
Reaction equation
[OH-].[Na+].[F:3][CH:4]([F:20])[O:5][C:6]1[C:7]([F:19])=[C:8]([CH:14]=[C:15]([F:18])[C:16]=1[F:17])[C:9]([O:11]CC)=[O:10].Cl>C(O)C>[F:20][CH:4]([F:3])[O:5][C:6]1[C:7]([F:19])=[C:8]([CH:14]=[C:15]([F:18])[C:16]=1[F:17])[C:9]([OH:11])=[O:10]Participants
Procedure
20 ml of a 6% w/v aqueous solution of sodium hydroxide were added to a solution of 5.79 g (0.021 moles) of ethyl 3-difluoromethoxy-2,4,5-trifluorobenzoate [(XXVI), X=X'=F, R16 =C2H5O] [prepared as described in step (b) above] in 40 ml of ethanol, and the mixture was left at room temperature overnight. The reaction mixture was then acidified by the addition of 3.5 ml of concentrated aqueous hydrochloric acid, and, after concentration by evaporation under reduced pressure, it was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, and then the solvent was removed by distillation under reduced pressure, to give 5.22 g of 3-difluoromethoxy-2,4,5-trifluorobenzoic acid as a colorless powder, melting at 68°-70° C.
Workup
- concentrationafter concentration
- customby evaporation under reduced pressure, it
- extractionwas extracted with ethyl acetate
- washThe extract was washed with water
- dry with materialdried over anhydrous sodium sulfate
- customthe solvent was removed by distillation under reduced pressure
Sources & evidence
- ORD record
- ord-a2cd1136365240f9ab333de187b0f66e
- Source dataset
- uspto-grants-1995_07
- Patent number
- US05436367
Reaction notes
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