Hydrochloric Acid → HCID 18985345, compound

HRID 1648652Notes

Reaction equation

HRID 1648652 reaction equation
[NH2:1][CH:2]1[CH:6]([O:7][CH2:8][C:9]([F:12])([F:11])[F:10])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.C(O)C.[ClH:23]>O>[ClH:23].[ClH:23].[NH2:1][CH:2]1[CH:6]([O:7][CH2:8][C:9]([F:12])([F:10])[F:11])[CH2:5][NH:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 15023848HCID 15023848, compound

Product 1

HCID 18985345HCID 18985345, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.61 g (0.006 mole) of 3-amino-1-t-butoxycarbonyl-4-(2,2,2-trifluoroethoxy)pyrrolidine [prepared as described in step (b) above], 30 ml of ethanol, 2 ml of concentrated aqueous hydrochloric acid and 4 ml of water was allowed to stand overnight an room temperature after which it was evaporated to dryness under reduced pressure, to afford 1.60 g of 3-amino-4-(2,2,2-trifluoroethoxy)pyrrolidine dihydrochloride as colorless crystals.

Workup

  1. customafter which it was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-8a26ef59ff9d40ae963da90661cdb1eb
Source dataset
uspto-grants-1995_07
Patent number
US05436367

Reaction notes

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