反应详情

4.82 g (0.045 mole) of benzylamine and 9.09 g (0.09 mole) of triethylamine were added to a solution of N-(3-fluoro-2-methylsulfonyloxypropyl)-N-(2-methylsulfonyloxyethyl)benzylamine [prepared as described in step (b) above] dissolved in 200 ml of ethanol. The mixture was heated under reflux for 2 hours and then concentrated by evaporation under reduced pressure. 100 ml of ethanol and 40 ml of a 2N aqueous solution of sodium hydroxide were added to the residue, and the mixture was concentrated by evaporation under reduced pressure. The residue was mixed with ethyl acetate, and insoluble materials were removed by filtration. The filtrate was freed from the solvent by evaporation under reduced pressure, and the residue was purified by column chromatography through silica gel using a 9:1 by volume mixture of toluene and ethyl acetate as the eluent, to afford 3.60 g of 1,4-dibenzyl-2-fluoromethylpiperazine as a yellow oil.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 2 hours
3. concentrationconcentrated by evaporation under reduced pressure
4. addition100 ml of ethanol and 40 ml of a 2N aqueous solution of sodium hydroxide were added to the residue
5. concentrationthe mixture was concentrated by evaporation under reduced pressure
6. additionThe residue was mixed with ethyl acetate, and insoluble materials
7. customwere removed by filtration
8. customThe filtrate was freed from the solvent by evaporation under reduced pressure
9. customthe residue was purified by column chromatography through silica gel using a 9:1
10. additionby volume mixture of toluene and ethyl acetate as the eluent