反应详情

A mixture of 40 g (0.14 m) of 1-chloro-2-(2,4-dichlorophenyl)hexan-2-ol and 38.6 g (0.57 m) of imidazole in 10 ml of dimethyl formamide is heated at 160° for one hour. The reaction mixture is cooled, poured into 300 ml of water and extracted with ether. The combined ether extracts are washed with water, then saturated sodium chloride solution and dried over MgSO4. Solvent is evaporated to give 42 g of a gummy brown solid, mp 78°-80°.

1. temperatureis heated at 160° for one hour
2. temperatureThe reaction mixture is cooled
3. extractionextracted with ether
4. washThe combined ether extracts are washed with water
5. dry with materialsaturated sodium chloride solution and dried over MgSO4
6. customSolvent is evaporated