Sodium Hydroxide → 1-[3-(4-Amino-2-methoxyphenoxy)-n-propyl]-4-phenylpiperazine

Participants

Reaction Steps

A mixture of 23.6 g of 1-[3-(4-acetamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine, 200 ml of 10% hydrochloric acid and 60 ml of conc. hydrochloric acid is refluxed for 2.5 hours. The mixture is adjusted to pH 11 by adding an aqueous 10% sodium hydroxide solution thereto. After cooling, the crystalline precipitates are collected by filtration, and then recrystallized from benzene. 14 g of 1-[3-(4-amino-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine are thereby obtained.

Provenance & Evidence