反应详情

A mixture of 23.6 g of 1-[3-(4-acetamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine, 200 ml of 10% hydrochloric acid and 60 ml of conc. hydrochloric acid is refluxed for 2.5 hours. The mixture is adjusted to pH 11 by adding an aqueous 10% sodium hydroxide solution thereto. After cooling, the crystalline precipitates are collected by filtration, and then recrystallized from benzene. 14 g of 1-[3-(4-amino-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine are thereby obtained.

1. temperatureis refluxed for 2.5 hours
2. temperatureAfter cooling
3. customthe crystalline precipitates
4. filtrationare collected by filtration
5. customrecrystallized from benzene