HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-{3-[4-(N-acetyl-N-(3-methyl-2-butenyl)-amino)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | HCID 12838122 | HCID 12838122 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-{3-[4-(N-acetyl-N-(3-methyl-2-butenyl)-amino)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine | HCID 20481757 | 86.3% |
Reaction Steps
2 g of 1-[3-(4- acetamido-2- methoxyphenoxy)-n-propyl]-4-phenyl-piperazine, 232 mg of 65% sodium hydride, 940 mg of 3-methyl-2- butenyl bromide and 60 ml of anhydrous dimethylformamide are treated in the same manner as described in Example 13. 1.78 g of 1-{3-[4-(N-acetyl-N-(3-methyl-2-butenyl)-amino)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine are thereby obtained as a pale yellow oil. Yield: 86.3%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04413006 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-ad8644db553b4e48af423cce2e6f4dc6 |
| Source note | uspto-grants-1983_11 |