2,2,6,6-Tetramethyl-4-piperidone → 5,5,7,7-Tetramethyl-1-oxa-6-azaspiro[2.5]octane

HRID 1648796Notes

Reaction equation

HRID 1648796 reaction equation
[CH3:1][O:2][Na].[CH3:4][C:5]1([CH3:14])[NH:11][C:10]([CH3:13])([CH3:12])[CH2:9][C:7](=O)[CH2:6]1>CC#N>[CH3:12][C:10]1([CH3:13])[CH2:9][C:7]2([CH2:1][O:2]2)[CH2:6][C:5]([CH3:14])([CH3:4])[NH:11]1

Participants

4

Reactant 2

HCID 132202,2,6,6-Tetramethyl-4-piperidoneHCID 178418582HCID 178418582, compound

Product 1

HCID 206710945,5,7,7-Tetramethyl-1-oxa-6-azaspiro[2.5]octane

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

44.55 g (0.825 mole) of CH3ONa were added to the mixture, under stirring, and, in half an hour, a solution of 77.5 g (0.5 mole) of triacetonamine dissolved in 50 cc of CH3CN was gradually added.

Workup

  1. waitin half an hour
  2. additionwas gradually added

Sources & evidence

ORD record
ord-5e04cf749018489f93e60a10a7559722
Source dataset
uspto-grants-1983_11
Patent number
US04413075

Reaction notes

Loading…