4-Fluorophenol → 2-Bromo-4-fluorophenol

HRID 1648847Notes

Reaction equation

HRID 1648847 reaction equation
[Br:1]Br.[F:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1>ClCCl>[Br:1][C:8]1[CH:9]=[C:4]([F:3])[CH:5]=[CH:6][C:7]=1[OH:10]

Participants

4

Reactant 2

HCID 97324-FluorophenolHCID 24408Bromine

Product 1

HCID 6054722-Bromo-4-fluorophenol

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At -20° C., 15.3 ml of bromine is dripped into 33.6 g of 4-fluorophenol in 300 ml of dichloromethane. After the solution has stood for 24 hours it is colorless. Distillation gives 46 g of 2-bromo-4-fluorophenol of boiling point 70° C./13.3 mbars.

Workup

  1. customAt -20° C.
  2. distillationDistillation

Sources & evidence

ORD record
ord-922d7c90abd24434a1a4a517ee4e1002
Source dataset
uspto-grants-1983_11
Patent number
US04414208

Reaction notes

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