Sodium Hydroxide → HCID 178515404, compound

HRID 1648857Notes

Reaction equation

HRID 1648857 reaction equation
Cl.[OH:2][C:3]1([CH2:13][C:14]2[N:18]=[CH:17][NH:16][N:15]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1.[OH-].[Na+]>O>[OH:2][C:3]1([CH2:13][C:14]2[N:18]=[CH:17][NH:16][N:15]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178479614HCID 178479614, compound

Product 1

HCID 178515404HCID 178515404, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 3.5 g (0.0132 mole) of 1,2,3,4-tetrahydro-1-hydroxy-1-[1-(1,2,4-triazolyl)methyl]-naphthalene hydrochloride in 200 ml of water is added 2.0 g (0.025 mole) of 50% NaOH, and the mixture is stirred. The organic material is extracted 2×100 ml of ether, and the extract is washed 2×50 ml of water, dried over anhydrous magnesium sulfate, and concentrated to give 2.6 g (85.9%) of the product, mp 105°-8°.

Workup

  1. extractionThe organic material is extracted 2×100 ml of ether
  2. washthe extract is washed 2×50 ml of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-31e4b24e104e46f8b6b75ad6d2e62949
Source dataset
uspto-grants-1983_11
Patent number
US04414210

Reaction notes

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