4H-1,2,4-Triazol-4-amine, 3,5-bis(2-chlorophenyl)- → Bekrxdrmajampz-uhfffaoysa-

HRID 1648875Notes

Reaction equation

HRID 1648875 reaction equation
N[N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:13])=[N:5][N:4]=[C:3]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20].N([O-])=O.[Na+]>C(O)(=O)C.O>[Cl:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:3]1[N:2]=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:13])[NH:5][N:4]=1

Participants

5

Reactant 2

HCID 8263064H-1,2,4-Triazol-4-amine, 3,5-bis(2-chlorophenyl)-HCID 23668193Sodium Nitrite

Product 1

HCID 11000759Bekrxdrmajampz-uhfffaoysa-Yield 52.3%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

The product of stage (a) (19.5 g) was dissolved in glacial acetic acid (100 ml) and was treated with sodium nitrite (4.4 g) in water (15 ml) at 10° C. The precipitated solid was filtered off, washed, dried and recrystallised from methanol to yield 9.7 g of desired product, mp 159°-160° C.

Workup

  1. filtrationThe precipitated solid was filtered off
  2. washwashed
  3. customdried
  4. customrecrystallised from methanol

Sources & evidence

ORD record
ord-b6f615d23d0a4bf48eee9775f236e28d
Source dataset
uspto-grants-1983_11
Patent number
US04414221

Reaction notes

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