Methyl iodide → 1-Methyl-3,5-bis(2-chlorophenyl)-1,2,4-triazole

Participants

Reaction Steps

The product of stage (b) (3.0 g) and sodium methoxide (0.57 g) were dissolved in methanol (75 ml) and treated with methyl iodide (1.3 g). After standing for 3 days the solution was evaporated to dryness, treated with water and extracted into dichloromethane. The extract was washed with water and dried. Evaporation yielded 0.8 g of a solid, mp 82°-85° C., which was recrystallised twice from petroleum ether (80°-100°).

Provenance & Evidence