反应详情

In a 500 ml. round-bottomed reaction flask equipped with magnetic stirrer, reflux condenser and nitrogen-inlet tube, there were placed 10 g. (0.032 mole) of crude 4-nitro-α,α'-dibromo-o-xylene [M. Kerfanto, Bulletin de la Societe Chimique de France, Vol. 12, p. 3537 (1965)] and 44.8 g. (0.526 mole) of piperidine (52 ml.) all dissolved in 100 ml. of benzene. The resulting mixture was then heated at the reflux point for a period of 18 hours and finally cooled to room temperature (~25° C.). The spent reaction mixture was then diluted with 500 ml. of benzene and thereafter washed with four-100 ml. portions of water, followed by drying over anhydrous magnesium sulfate. After removal of the drying agent by means of filtration and the solvent by means of evaporation under reduced pressure, there was obtained a 59% yield of crude 1,1'-[4-nitro-1,2-phenylenebis(methylene)]bispiperidine as a residue in the form of a yellow oil.

1. customround-bottomed reaction flask equipped with magnetic stirrer
2. temperaturereflux condenser and nitrogen-inlet tube
3. temperatureThe resulting mixture was then heated at the reflux point for a period of 18 hours
4. customThe spent reaction mixture
5. additionwas then diluted with 500 ml
6. washof benzene and thereafter washed with four-100 ml
7. dry with materialby drying over anhydrous magnesium sulfate
8. customAfter removal of the drying agent
9. filtrationby means of filtration
10. customthe solvent by means of evaporation under reduced pressure