Benzyl 4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-azepine-1-carboxylate → 4-Chloro-5-cyano-2,3,6,7-tetrahydro-1H-azepine hydrochloride

Participants

Reaction Steps

1.45 gm (0.005 mol) of benzyl 4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-1-azepine-carboxylate were dissolved in 20 ml of ethyl alcohol by addition of 0.9 ml of semiconcentrated hydrochloric acid, and after the addition of 0.2 gm of palladium-on-charcoal, the mixture was hydrogenated in an autoclave at room temperature and under a hydrogen pressure of 5 bars. After half an hour, the uptake of hydrogen had ended. The catalyst was filtered off, and the filtrate was evaporated in vacuo. The residue was recrystallized from isopropyl alcohol.

Provenance & Evidence