反应详情

1.45 gm (0.005 mol) of benzyl 4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-1-azepine-carboxylate were dissolved in 20 ml of ethyl alcohol by addition of 0.9 ml of semiconcentrated hydrochloric acid, and after the addition of 0.2 gm of palladium-on-charcoal, the mixture was hydrogenated in an autoclave at room temperature and under a hydrogen pressure of 5 bars. After half an hour, the uptake of hydrogen had ended. The catalyst was filtered off, and the filtrate was evaporated in vacuo. The residue was recrystallized from isopropyl alcohol.

1. customwas hydrogenated in an autoclave at room temperature and under a hydrogen
2. waitAfter half an hour
3. filtrationThe catalyst was filtered off
4. customthe filtrate was evaporated in vacuo
5. customThe residue was recrystallized from isopropyl alcohol