Hydrazine hydrate (1:1) → HCID 13072060, compound

HRID 1648937Notes

Reaction equation

HRID 1648937 reaction equation
[CH2:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([C:14]([O:16]CC)=O)[S:13][C:7]=2[CH2:6][CH2:5]1)[CH2:2][CH3:3].O.[NH2:20][NH2:21]>C(O)C>[CH2:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([C:14]([NH:20][NH2:21])=[O:16])[S:13][C:7]=2[CH2:6][CH2:5]1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13072053HCID 13072053, compound

Product 1

HCID 13072060HCID 13072060, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

13.0 gm (0.0486 mol) of ethyl 5,6,7,8-tetrahydro-6-propyl-4H-thieno[2,3-d]azepine-2-carboxylate were dissolved in 15 ml of absolute ethyl alcohol, and the solution was refluxed for 3 hours with 14 ml (0.23 mol) of 80% hydrazine hydrate. After cooling, the mixture was concentrated by evaporation in vacuo, and the residue was recrystallized from isopropyl alcohol.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated by evaporation in vacuo
  3. customthe residue was recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-b9a9150c3d5e4b6a8e008a4f71a81fc5
Source dataset
uspto-grants-1983_11
Patent number
US04414225

Reaction notes

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