Acetic Acid → HCID 70532075, compound

HRID 1648969Notes

Reaction equation

HRID 1648969 reaction equation
[N:1]12[CH2:9][CH2:8][CH2:7][CH:6]1[CH2:5][NH:4][CH2:3][CH2:2]2.C(O)(=O)C.[CH:14]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[CH2:15]>CO>[N:19]1[CH:20]=[CH:21][C:16]([CH2:14][CH2:15][N:4]2[CH:3]=[CH:2][N:1]3[CH:9]=[CH:8][CH:7]=[C:6]3[CH2:5]2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 75024-VinylpyridineHCID 558578Octahydropyrrolo(1,2-a)pyrazine

Product 1

HCID 70532075HCID 70532075, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 12 g (0.095 mole) 1,4-diazabicyclo[4.3.0]-nonane, 10 ml of acetic acid and 12.5 ml of 4-vinylpyridine in 225 ml methanol was heated at reflux for 20 hours. The solvent was removed under vacuum and the residue distilled to yield 5.1 g of 2(4-pyridylethyl)pyrrolo[1,2-a]pyrazine; b.p. 126°-130/0.01 mm.

Workup

  1. temperatureat reflux for 20 hours
  2. customThe solvent was removed under vacuum
  3. distillationthe residue distilled

Sources & evidence

ORD record
ord-e82213dc57e44b46be0efe9df57f17d6
Source dataset
uspto-grants-1983_11
Patent number
US04414389

Reaction notes

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