Hydrochloric Acid → HCID 70531777, compound

Participants

Reaction Steps

A pressure bottle was charged with 1 g PtO2, 4.5 g of 2-(4-pyridylethyl)pyrrolo[1,2-a]pyrazine (0.0195 mole), 180 ml aqueous ethanol (2/1), and 13 ml of concentrated hydrochloric acid and shaken under 60 psi on a Parr hydrogenation apparatus. When hydrogenation was completed the reaction mixture was filtered free of catalyst, the catalyst washed with ethanol and the combined filtrate concentrated under reduced pressure. The residue was crystallized from methanol. There was obtained 5.5 g (80%) of 2-(4-piperidylethyl)-pyrrolo[1,2-a]pyrazine as the hydrochloride; m.p. 295°-298° C.

Provenance & Evidence