Hydrochloric Acid → HCID 70531777, compound

HRID 1648970Notes

Reaction equation

HRID 1648970 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][N:9]2[CH:14]=[CH:13][N:12]3[CH:15]=[CH:16][CH:17]=[C:11]3[CH2:10]2)=[CH:3][CH:2]=1.Cl>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][N:9]2[CH:14]=[CH:13][N:12]3[CH:15]=[CH:16][CH:17]=[C:11]3[CH2:10]2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70532075HCID 70532075, compound

Product 1

HCID 70531777HCID 70531777, compoundYield 121.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A pressure bottle was charged with 1 g PtO2, 4.5 g of 2-(4-pyridylethyl)pyrrolo[1,2-a]pyrazine (0.0195 mole), 180 ml aqueous ethanol (2/1), and 13 ml of concentrated hydrochloric acid and shaken under 60 psi on a Parr hydrogenation apparatus. When hydrogenation was completed the reaction mixture was filtered free of catalyst, the catalyst washed with ethanol and the combined filtrate concentrated under reduced pressure. The residue was crystallized from methanol. There was obtained 5.5 g (80%) of 2-(4-piperidylethyl)-pyrrolo[1,2-a]pyrazine as the hydrochloride; m.p. 295°-298° C.

Workup

  1. filtrationwas filtered free of catalyst
  2. washthe catalyst washed with ethanol
  3. concentrationthe combined filtrate concentrated under reduced pressure
  4. customThe residue was crystallized from methanol

Sources & evidence

ORD record
ord-9c79698885404c11bb3356893155ee89
Source dataset
uspto-grants-1983_11
Patent number
US04414389

Reaction notes

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