Benzene → (2,4-dimethylphenyl)-(3-methylphenyl)methanone

HRID 1648998Notes

Reaction equation

HRID 1648998 reaction equation
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](Cl)=[O:8])[CH:2]=1.C[C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1.Cl.[CH:20]1C=CC=CC=1>>[CH3:18][C:15]1[CH:16]=[C:17]([CH3:20])[CH:12]=[CH:13][C:14]=1[C:7]([C:3]1[CH:4]=[CH:5][CH:6]=[C:1]([CH3:10])[CH:2]=1)=[O:8]

Participants

5

Reactant 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 7809P-XyleneHCID 743753-Methylbenzoyl chloride

Product 1

HCID 349077(2,4-dimethylphenyl)-(3-methylphenyl)methanone

Procedure

A mixture of 15.46 g (0.1 mole) of m-toluoyl chloride, 24.6 ml (0.2 mole) of p-xylene, and 2 g of MoS2 was stirred and refluxed. After 24 hours no more HCl evolved. The mixture was diluted with 100 ml of benzene, filtered from 2 g of MoS2, and distilled to obtain 12.5 g boiling at 245°-250° C./200 of 2,4,3'-trimethylbenzophenone, 82.6 mole % yield.

Workup

  1. temperaturerefluxed
  2. filtrationfiltered from 2 g of MoS2
  3. distillationdistilled

Sources & evidence

ORD record
ord-5503e684ff414183a15f6b7ace7b9140
Source dataset
uspto-grants-1983_11
Patent number
US04414406

Reaction notes

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