反应详情

6-Nitro-8-hydroxy-3,4-dihydrocarbostyril (10 g) and potassium carbonate (13.3 g) were mixed with acetone (70 ml) and water (70 ml) and the mixture was refluxed with adding dropwise 12.1 g of dimethyl sulfate. After refluxing was continued for 4 hours, the reaction mixture was cooled, and crystals which precipitated were collected by filtration and washed with water to give 8.22 g of 6-nitro-8-methoxy-3,4-dihydrocarbostyril.

1. temperaturethe mixture was refluxed
2. temperatureAfter refluxing
3. temperaturethe reaction mixture was cooled
4. customcrystals which precipitated
5. filtrationwere collected by filtration
6. washwashed with water