反应详情

温度

70 °C

To a solution of 8-hydroxycarbostyril (27 g) and chloroacetyl chloride (37 ml) in ntirobenzene (250 ml) was added aluminum chloride (85 g) portionwise and the mixture was stirred at 70° C. for 20 hours. After adding 10% hydrochloric acid (500 ml), nitrobenzene was removed by steam distillation. After cooling, crystals which formed were collected by filtration, washed with 300 ml of hot water and recrystallized from methanol to give 4.0 g of 5-chloroacetyl-8-hydroxycarbostyril.

1. customwas removed by steam distillation
2. temperatureAfter cooling
3. customcrystals which formed
4. filtrationwere collected by filtration
5. washwashed with 300 ml of hot water
6. customrecrystallized from methanol