Methyl iodide → HCID 20481482, compound

HRID 1649019Notes

Reaction equation

HRID 1649019 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[N:7][C:6]=1[C:14]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]2[C:15]=1[CH:16]=[CH:17][C:18](=[O:26])[NH:19]2)[CH3:3].[CH3:27][I:28]>C(#N)C>[OH2:24].[OH2:24].[OH2:24].[I-:28].[CH3:3][N+:2]([CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[N:7][C:6]=1[C:14]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]2[C:15]=1[CH:16]=[CH:17][C:18](=[O:26])[NH:19]2)([CH3:27])[CH3:1]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13260265HCID 13260265, compound

Product 1

HCID 20481482HCID 20481482, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

To a suspension of 5-(3-dimethylaminomethylimidazo[1,2-a]pyridine-2-yl)-8-methoxycarbostyril (1.5 g) in acetonitrile (20 ml) was added methyl iodide (1.5 ml) and the mixture was stirred at 40° C. for 1 hour. Crystals thus formed were collected by filtration and recrystallized from water to give 1.7 g of 5-(3-trimethylammoniomethylimidazo[1,2-a]pyridine-2-yl)-8-methoxycarbostyril iodide trihydrate.

Workup

  1. customCrystals thus formed
  2. filtrationwere collected by filtration
  3. customrecrystallized from water

Sources & evidence

ORD record
ord-c1b45834122b4ede8c4aeba3fc3ccd2b
Source dataset
uspto-grants-1983_11
Patent number
US04414390

Reaction notes

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