Piperazine → HCID 21842420, compound

HRID 1649077Notes

Reaction equation

HRID 1649077 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:16])[N:3]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:16])[N:3]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 12852450HCID 12852450, compound

Product 1

HCID 21842420HCID 21842420, compoundYield 95.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Amino-4-chloro-6-(2,5-dichlorophenyl)-s-triazine (1.3 grams) and 2.0 grams of piperazine were stirred with refluxing for two hours in 20 milliliters of dioxane. The reaction solution was evaporated to dryness in vacuo, water was added to the residue, crystals thereby separated out were collected by filtration, and washed with methanol to give 1.47 grams of 2-amino-4-piperazino-6-(2,5-dichlorophenyl)-s-triazine, melting at 194° to 195° C.

Workup

  1. customThe reaction solution was evaporated to dryness in vacuo, water
  2. additionwas added to the residue, crystals
  3. customthereby separated out
  4. filtrationwere collected by filtration
  5. washwashed with methanol

Sources & evidence

ORD record
ord-837bf2a57b73481096fdd05bd575204d
Source dataset
uspto-grants-1983_11
Patent number
US04415570

Reaction notes

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