HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 3-Phenyl-1H-5-indazolecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Formate | HCID 2723810 | — |
| Reactant | 3-Phenyl-1H-indazole-5-carbaldehyde | HCID 13066955 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 3-Phenyl-1H-5-indazolecarbonitrile | HCID 13066956 | 76% |
Reaction Steps
A mixture of 22 g of 5-formyl-3-phenylindazole, 8 g of hydroxylamine hydrochloride and 12.5 g of sodium formate was added to 150 ml of formic acid, and after refluxing for 2 hours, the mixture was extracted with chloroform. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated to give 16.5 g of 5-cyano-3-phenylindazole (m.p. 150°-151° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415569 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-ddde8d3f43fc41eea8b0eccd7d00c7dc |
| Source note | uspto-grants-1983_11 |