反应详情

A mixture of 22 g of 5-formyl-3-phenylindazole, 8 g of hydroxylamine hydrochloride and 12.5 g of sodium formate was added to 150 ml of formic acid, and after refluxing for 2 hours, the mixture was extracted with chloroform. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated to give 16.5 g of 5-cyano-3-phenylindazole (m.p. 150°-151° C.).

1. temperatureafter refluxing for 2 hours
2. extractionthe mixture was extracted with chloroform
3. washThe extract was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated