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HRID1649117

反应详情

EQUATION

反应方程式

HRID 1649117 的结构方程式

REACTANTS

反应物

4
结构：O=c1[nH]cc(F)c(=O)[nH]1
HCID3385

5-Fluorouracil

C4H3FN2O2

结构：CC(=O)Oc1ccc(C=O)cc1OC(C)=O
HCID1517488

3,4-Diacetoxybenzaldehyde

C11H10O5

结构：CC(=O)Oc1ccc(C2OCCO2)cc1OC(C)=O
HCID20480611

未命名化合物

结构：C[Si](C)(C)c1[nH]c(=O)n([Si](C)(C)C)c(=O)c1F
HCID68585259

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)OCCOC(c1ccc(OC(C)=O)c(OC(C)=O)c1)n1cc(F)c(=O)[nH]c1=O
HCID15583560

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：OCCO
溶剂HCID174

Ethylene glycol

C2H6O2

PROCEDURE

实验过程

Bis(trimethylsilyl)-5-fluorouracil prepared from 5-fluorouracil (10 g) , and 2-(3,4-diacetoxyphenyl)-1,3-dioxolan (26.6 g) prepared from 3,4-diacetoxybenzaldehyde and ethyleneglycol were treated as in Example 10 and the product was acetylated to give 7.4 g of crystalline 1-[α-(2-acetoxyethoxy)-3,4-diacetoxybenzyl]-5-fluorouracil.

WORKUP

后处理

  1. additionwere treated as in Example 10