HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 2-Nitro-5-piperazinylcinnamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Nitro-5-piperazinylbenzaldehyde hydrochloride | HCID 13236300 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Nitro-5-piperazinylcinnamic acid | HCID 57012325 | 87.6% |
Reaction Steps
2-Nitro-5-piperazinylbenzaldehyde hydrochloride (47 g) was dissolved in 500 ml of pyridine and 5 g of piperidine and 100 g of malonic acid were added to the solution followed by heating under reflux for 5 hours. After cooling, crystals which formed were collected by filtration to give 42 g of 2-nitro-5-piperazinylcinnamic acid, m.p. 229°-237° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415572 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-48eade3e6a474d77b242f2486351ebb8 |
| Source note | uspto-grants-1983_11 |