反应详情

2-Nitro-5-piperazinylbenzaldehyde hydrochloride (47 g) was dissolved in 500 ml of pyridine and 5 g of piperidine and 100 g of malonic acid were added to the solution followed by heating under reflux for 5 hours. After cooling, crystals which formed were collected by filtration to give 42 g of 2-nitro-5-piperazinylcinnamic acid, m.p. 229°-237° C.

1. temperatureby heating
2. temperatureunder reflux for 5 hours
3. temperatureAfter cooling
4. customcrystals which formed
5. filtrationwere collected by filtration