Sodium Hydroxide → 8-Amino-3,4-dihydro-2(1H)-quinolinone

HRID 1649205Notes

Reaction equation

HRID 1649205 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13317111HCID 13317111, compound

Product 1

HCID 133171138-Amino-3,4-dihydro-2(1H)-quinolinoneYield 0.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

8-Acetylamino-3,4-dihydrocarbostyril (11.8 g, 57.8 mols) was suspended in 90 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hours. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide followed by adjusting to pH of about 8. Crystals which precipitated were collected by filtration to give 7.87 g of 8-amino-3,4-dihydrocarbostyril.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hours
  3. customCrystals which precipitated
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f5a947b5920741e381580035a8177c62
Source dataset
uspto-grants-1983_11
Patent number
US04415572

Reaction notes

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