反应详情

5-(1-Piperazinyl)-3,4-dihydrocarbostyril (2.6 g) and 2.34 ml of triethylamine were added to 50 ml of chloroform. The mixture was stirred at room temperature while slowly adding dropwise 10 ml of chloroform solution containing 2.3 g of 4-methylbenzoyl chloride. After completion of addition, the reaction mixture was stirred for 30 minutes. After completion of reaction, 100 ml of chloroform and then a large amount of water was added to separate chloroform and the chloroform layer was washed with sodium hydrogencarbonate solution and subsequently with water and dried over anhydrous sodium sulfate. Chloroform was distilled off and residual crystals were recrystallized from chloroformether to give 1.8 g of 5-[4-(4-methylbenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 239.5°-240° C., colorless powders.

1. additionAfter completion of addition
2. stirringthe reaction mixture was stirred for 30 minutes
3. customto separate chloroform
4. washthe chloroform layer was washed with sodium hydrogencarbonate solution and subsequently with water
5. dry with materialdried over anhydrous sodium sulfate
6. distillationChloroform was distilled off
7. customresidual crystals were recrystallized from chloroformether