Propargyl bromide → HCID 13236341, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1 g of 5-(1-piperazinyl)-3,4-dihydrocarbostyril, 30 ml of DMF and 900 mg of sodium carbonate was added 491 mg of propargyl bromide and the mixture was stirred at 80° C. for 3 hours. The reaction mixture was poured into a large amount of saturated saline solution and extracted with chloroform. After washing with water, the extract was dried over anhydrous sodium sulfate. Then, chloroform was distilled off and the residue was purified through silica gel column chromatography and recrystallized from chloroform to give 0.1 g of 5-[4-(2-propynyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 225°-226° C., pale yellow powders.

Provenance & Evidence