HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 6-(1-Piperazinyl)carbostyril hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ethanamine, 2-bromo-N-(2-bromoethyl)-, hydrobromide (1:1) | HCID 12692731 | — |
| Reactant | 6-Aminoquinolin-2-ol | HCID 12810797 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(1-Piperazinyl)carbostyril hydrobromide | HCID 13236367 | 45.4% |
Reaction Steps
A mixture of 25 g of 6-aminocarbostyril, 50 g of bis(β-bromoethyl)amine hydrobromide and DMF was stirred at 80°-90° C. for 3 hours. After cooling to room temperature, 8.2 g of Na2CO3 was added to the mixture and stirred at 80°-90° C. for 4 hours. After cooling to room temperature, crystals which precipitated were collected by filtration, washed with ethanol and dried to give 22 g of 6-(1-piperazinyl)carbostyril hydrobromide, m.p. above 300° C., pale yellow rhombic crystals (water-ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415572 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-e17659afadd64e2e854ebe9613ea07c5 |
| Source note | uspto-grants-1983_11 |