反应详情

A mixture of 25 g of 6-aminocarbostyril, 50 g of bis(β-bromoethyl)amine hydrobromide and DMF was stirred at 80°-90° C. for 3 hours. After cooling to room temperature, 8.2 g of Na2CO3 was added to the mixture and stirred at 80°-90° C. for 4 hours. After cooling to room temperature, crystals which precipitated were collected by filtration, washed with ethanol and dried to give 22 g of 6-(1-piperazinyl)carbostyril hydrobromide, m.p. above 300° C., pale yellow rhombic crystals (water-ethanol).

1. stirringstirred at 80°-90° C. for 4 hours
2. temperatureAfter cooling to room temperature
3. customcrystals which precipitated
4. filtrationwere collected by filtration
5. washwashed with ethanol
6. customdried