Hydrochloric Acid → HCID 13242429, compound

HRID 1649296Notes

Reaction equation

HRID 1649296 reaction equation
C([O:3][C:4](=[O:22])[CH:5]([O:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:9]=1)[CH3:6])C.[OH-].[Na+].Cl>O.C(O)C>[F:15][C:14]([F:16])([F:17])[C:12]1[CH:13]=[C:8]([CH:9]=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:11]=1)[O:7][CH:5]([CH3:6])[C:4]([OH:22])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13242428HCID 13242428, compound

Product 1

HCID 13242429HCID 13242429, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Conditions

Temperature
5 °C

Procedure

A stirred charge containing 0.05 mole of ethyl-2-[3,5-bis-(trifluoromethyl)phenoxy]propionate, 150 ml of ethyl alcohol, 8 g (0.1 mole) of 50% aqueous solution of sodium hydroxide and 25 ml of water was heated at reflux for 5 hours and at 25°-30° C. for 18 hours. After cooling to 5° C. 800 ml of water containing 15 g (0.15 mole) of concentrated hydrochloric acid was added slowly. After stirring at 0°-10° C. for one hour, the resulting solid was collected by filtration, washed with cold water and air-dried at 25°-30° C. A product with a melting point of 51°-53° C. was obtained with a yield of 97%.

Workup

  1. additionA stirred charge
  2. temperaturewas heated
  3. temperatureat reflux for 5 hours and at 25°-30° C. for 18 hours
  4. filtrationthe resulting solid was collected by filtration
  5. washwashed with cold water
  6. customair-dried at 25°-30° C
  7. customA product with a melting point of 51°-53° C. was obtained with a yield of 97%

Sources & evidence

ORD record
ord-1765591146d042fca5f9a268f056ba82
Source dataset
uspto-grants-1983_11
Patent number
US04416687

Reaction notes

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