Hydrochloric Acid → HCID 13242430, compound

HRID 1649297Notes

Reaction equation

HRID 1649297 reaction equation
C([O:3][C:4](=[O:23])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=1)C.[OH-].[Na+].Cl>O.C(O)C>[F:16][C:15]([F:17])([F:18])[C:13]1[CH:14]=[C:9]([CH:10]=[C:11]([C:19]([F:21])([F:22])[F:20])[CH:12]=1)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:23])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13242433Ethyl 4-[3,5-bis(trifluoromethyl)phenoxy]butanoate

Product 1

HCID 13242430HCID 13242430, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Conditions

Temperature
5 °C

Procedure

A stirred charge containing 0.05 mole of ethyl-4-[3,5-bis-(trifluoromethyl)phenoxy]butyrate, 150 ml of ethyl alcohol, 8 g (0.1 mole) of 50% aqueous solution of sodium hydroxide and 25 ml of water was heated at reflux for 5 hours and at 25°-30° C. for 18 hours. After cooling to 5° C., 800 ml of water containing 15 g (0.15 mole) of concentrated hydrochloric acid was added slowly. After stirring at 0°-10° C. for one hour, the resulting solid was collected by filtration, washed with cold water and air dried at 25°-30° C. A product with a melting point of 85°-87° C. was obtained with a yield of 87%.

Workup

  1. additionA stirred charge
  2. temperaturewas heated
  3. temperatureat reflux for 5 hours and at 25°-30° C. for 18 hours
  4. filtrationthe resulting solid was collected by filtration
  5. washwashed with cold water and air
  6. customdried at 25°-30° C
  7. customA product with a melting point of 85°-87° C. was obtained with a yield of 87%

Sources & evidence

ORD record
ord-eae33f443706413592c1786f22460e3f
Source dataset
uspto-grants-1983_11
Patent number
US04416687

Reaction notes

Loading…