2,6-Dimethoxybenzoyl chloride → HCID 13239360, compound

HRID 1649324Notes

Reaction equation

HRID 1649324 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:4]=1[C:5](Cl)=[O:6].[NH2:14][C:15]1[S:16][C:17]([C:20]2([CH3:26])[S:25][CH2:24][CH2:23][CH2:22][S:21]2)=[N:18][N:19]=1>C1(C)C=CC=CC=1.CCCCC>[CH3:26][C:20]1([C:17]2[S:16][C:15]([NH:14][C:5](=[O:6])[C:4]3[C:3]([O:2][CH3:1])=[CH:11][CH:10]=[CH:9][C:8]=3[O:12][CH3:13])=[N:19][N:18]=2)[S:21][CH2:22][CH2:23][CH2:24][S:25]1

Participants

5

Reactant 2

HCID 748102,6-Dimethoxybenzoyl chlorideHCID 19911947HCID 19911947, compound

Product 1

HCID 13239360HCID 13239360, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8003PentaneSolvent

Procedure

A solution of 1.0 g of 2,6-dimethoxybenzoyl chloride in 50 ml of toluene containing 1.0 g of 2-amino-5-(2-methyl-1,3-dithian-2-yl)-1,3,4-thiadiazole was heated at reflux for fifteen hours. The reaction mixture was then cooled to room temperature and diluted with pentane, whereupon a white precipitate formed. The precipitate was collected by filtration and identified as N-[5-(2-methyl-1,3-dithian-2-yl)-1,3,4-thiadiazol-2-yl]-2,6-dimethoxybenzamide.

Workup

  1. temperatureat reflux for fifteen hours
  2. customformed
  3. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-fbafb994b96f455bb380ca4604c4d869
Source dataset
uspto-grants-1983_11
Patent number
US04416683

Reaction notes

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